HEDGEHOG PATHWAY INHIBITORS FOR LOCALLY ADVANCED AND METASTATIC BASAL CELL CARCINOMA: A REAL-WORLD SINGLE-CENTER RETROSPECTIVE REVIEW.

Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review.

Basal cell carcinoma (BCC) is highly curable by surgical excision or radiation.In rare cases, BCC can be locally destructive or difficult to surgically remove.Hedgehog inhibition (HHI) with vismodegib or sonidegib induces a 50-60% response rate.Long-term toxicity includes muscle spasms and weight loss leading to dose decreases.This retrospective ch

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Evaluation of determining factors of underground hydrosphere evolution within urban areas (on the example of Irkutsk)

The relevance of the discussed issue.Studying the anthropogenic evolution and transformation of underground hydrosphere within urbanized territories is the relevant issue nowadays.Underflooding and forming Carpet Replacement Kits of technogenic aquifers cause serious geological hazards, that has been seen in some districts of Irkutsk.That fact sets

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